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The updated 2021 WHO global air quality guidelines 273 recommend annual mean PM 2.5 concentrations of 5 g/m 3 , while the EPA primary standard 274 is 12 g/m 3 , with a proposal in January 2023 to revise this standard to 9.010.0 g/m 3 (ref

This promotes anabolic processes, such as tissue repair, fat metabolism, and muscle building

Importantly, THC does not interact with the brain in equal measure, as found by Leishman et al

The liver, which houses the highest glutathione concentrations and performs extensive detoxification work during sleep, may benefit from elevated glutathione availability during these nighttime processes